CC disruption in the expanded polyA stretch [mutants RUNX2(+12andc−/#2) and /#3; Fig. 4D, middle and right panels] strongly reduces both mislocalization and aggregation with respect to the polyA-expanded form of RUNX2 [ P < 0.001 versus RUNX2(+12A), Tukey HSD post hoc test, in all instances; Fig. 4F and H].
Indeed, we observed similar levels of infection and bacterial aggregation with the mptC mutant and the wildtype M. marinum when 2.4-fold more mptC mutant than wildtype bacteria were used (Fig. 2).
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It was observed that the nanoparticles obtained were highly discrete, were circular in shape and did not show aggregation with the neighbouring particles.
In addition, PD is a slowly progressing disorder and a correlation of αSynuclein aggregation with the progressive loss of nigral DA neurons has not been assessed so far.
As in the human diseases, the polyglutamine-YFP peptides show age-dependent aggregation, with the rapidity of aggregation and cytotoxicity correlating strongly with the length of the polyglutamine repeat.
More specifically, the results indicate that plant toxicity is associated with easy bleeding, easy bleeding with the absence of defensive body movements, a solitary habit with dropping and/or violent movements, aggregation with the absence of defensive movements, and true gregariousness with raising abdomen (Additional file 5).
Moreover, the mRNA levels of differentiation-marker genes (collagen types I and II) were regulated in accordance with the morphological analyses concerning the cell migration and aggregation in the cultures with and without TGFβ1.
Thus, in other examples of neurodegenerative disease associated with protein misfolding and aggregation, the aggregation rates of the causative protein appears to best correlate with disease onset.
Deposition and aggregation theory combined with the diffusion and thermal conductivity (alone) (8.33% of the sample). .
