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The interaction between the MS status and advanced stage in their association with S-CRC indicated the need to analyse separately the prognosis of MSI and MSS S-CRC.
While there was no report showing such relationship in gastric cancer, a study demonstrated a significant association between high expression of MRP1 and advanced stage in breast cancer suggesting the role of MRP1 as a marker of aggressive tumour behaviour (Filipits et al, 1996).
It also showed that expression of LNβ3 was associated with the extent of invasion and advanced stage in gastric cancer.
Decreased E-cadherin expression is associated with poor prognosis, high histological grade and advanced stage in endometrial cancer [ 20- 22].
Viswanathan et al. [26] showed that LIN28B overexpression was associated with high serum AFP level and advanced stage in 89 HCV-related HCC patients.
In the middle and advanced stages of OA, the cartilage was thicker in the DHEA groups than in the placebo groups.
A number of investigational anti-AD drugs, targeting various processes characteristic of AD pathogenesis, have failed in recent clinical trials [ 1, 4- 6], likely due to massive neuronal loss and advanced stages of the disease in the enrolled patients [ 3- 5].
The 3-year event-free survival rate in the GETH/GITMO-2008 GETH/GITMO-200831%, and 25% for patrials transplanted in early, intermediate, and advanced stages of the disease, respectively (P < .0001).
The animals were scanned in vivo by micro-CT at two, six, and ten weeks post-injection, analogous to early, intermediate, and advanced stages of OA, to assess architectural changes in the tibial subchondral bone.
22. Due to the dramatic losses of habitat, increase in population, and advanced stage of bushmeat commerce in many areas of the region, and based on current trends in Central Africa, declines in wildlife resource availability may account for the decline seen in some harvest and consumption rates (as suggested by the studies in Cote d'Ivoire).
However, eradicating large solid tumors in advanced stages of the disease remains challenging.
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