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c-Src non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and the relationship between activation and cancer progression appears significant (Irby and Yeatman, 2000).
The dried materials were powdered and activated in a muffle furnace kept at 800 °C for a period of 10 min.
EGFR is overexpressed and activated in a variety of tumors and provides an attractive target for anti-cancer therapy (reviewed in [9]).
We found Cyp2b10, a known CAR target, to be concomitantly hypomethylated and activated in a tissue-specific manner following PB treatment and revealed a PB-mediated epigenetic switch at the promoter of this gene.
We show that Cyp2b10, a direct and early target of the CAR pathway [37], is concomitantly hypomethylated and activated in a tissue-specific manner following PB treatment, and further characterize an epigenetic switch from a repressive to an active chromatin configuration at this locus.
The Rp1-D21 phenotype can be suppressed and activated in a reversible manner by altering the external temperature.
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For chromatographical analysis HTPLC-plates (silica gel 60, 20 × 10 cm, Merck, Darmstadt, Germany) were pre-cleaned in chloroform and methanol 1 1 (v/v) and activated in an oven at 110°C for 10 min.
While Snf1 activation has been studied predominantly in the context of glucose repression, Snf1 is phosphorylated and activated in response to a number of environmental stresses.
GS is dephosphorylated and activated in response to an insulin signal in muscle and to a glucose-signal in the liver [18].
In addition, CEBPβ has been shown to be phosphorylated and activated in response to an increase in the intracellular calcium concentration, which was caused by the activation of CaMKKβ [ 55].
Mast cells (MCs) are part of the innate immune system and are recruited to and activated in the microenvironment of a developing tumor.
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