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Interestingly, shorter periods of exposure to SN-38 (72 h) at concentrations that determined a 50% of inhibition of endothelial cell proliferation showed a significant increase of secreted TSP-1 (P<0.05) in conditioned media and a weak decrease in VEGF (P>0.05).
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If we define "preferential translation" as an increase of translation and "resistance" as a weak decrease in translation, then genes with a high Z-score and a fold change >1 should be classified as "preferentially translated" and those with high a Z-score and a fold change <1 as "tolerant".
This band vanishes upon cycling to 1.1 V versus the reversible hydrogen electrode (VRHE) and the catalyst shows a weak decrease in grain size in AFM.
Furthermore, none of the genes associated to the biosynthetic Kennedy's Pathway resulted differentially expressed between CHKA-silenced and control cells apart from a weak decrease (0.8-fold change in expression, FDR=0.21 and P=0.0049) of the GDPD5 gene, involved in the catabolic pathway leading to Choline formation (Supplementary Table 1).
YFP RNAi resulted in a strong decrease in polyQ-YFP levels in Q40Bristol, and a weaker decrease in Q40DR1350.
However, only a weak decrease of the intensity of the RhB peaks, and no peak shifts were found at pH 4 and pH 6.
Only a weak decrease of surface hydrophilicity was measured after the treatments and steam-sterilization.
For all strain amplitudes a virtually stationary state develops after about 10% of the lifetime with only a weak decrease of the peak stresses.
We observe a weak but statistically significant decrease in τ c with increased blood flow, as well a weak decrease with increased inter-particle distance that does not reach a p<0.01 significance level.
The quantification of cancer cell VEGF immunoreactivity confirmed that there was only a weak decrease in treated groups without reaching a significant difference.
Overexpression of caspase-10B resulted in a weak decrease in Fas-sensitivity in SW480 cells, as observed in SH-EP cells.
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