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The nucleophilic water molecule is displaced and a unique mode of binding is observed with the S-OH of the inhibitor occupying the oxyanion binding site of the proposed tetrahedral intermediate.
Hence, the KGD has a reversed J-shape and a unique mode at x=0 when α≤1.
This is an unusual way of forming a cleavage furrow and a unique mode of cytokinesis that has not yet been observed in any other eukaryote.
Paclitaxel has a wide range of activities in vivo against relatively drug-resistant solid tumours and a unique mode of action.
These results indicate a novel mechanism to repress protein synthesis by Eif1a-like genes and a unique mode of protein synthesis regulation in ES cells, which undergo a transient and reversible repression of global protein synthesis in the Zscan4-positive state.
Similar(55)
MLFD is a flexible distribution with varying shapes and has a unique mode at zero or it is unimodal with one/two non-zero modes.
This coordination links PG synthesis with OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modulating PBP1B cross-linking activity.
Furthermore, for the first instance, we identified H3K36me2 as a global repressive mark in P. falciparum and revealed a unique mode of regulation of gene expression by altering the ratio of activation and repression marks.
15– 17 Eribulin shows preclinical antitumor activity against a wide variety of human cancer types and has a unique mode of action on microtubule dynamics, causing antimitotic, apoptosis-inducing activities.
The co-crystal structures with PPARγ and RXRα revealed a unique mode of dual PPARγ/RXR agonism by magnolol [29].
However, it bound to RXRα with a unique mode and acted as an RXRα antagonist (Figs. 1, 2 and 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com