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Conversely, in SH-SY 5Y cells, the inhibition of ER Ca2+ release mediated by Akt overexpression is negligible, with no significative differences in the ER plateau values (329.46±11.09 μM control versus 308.25±11.18 μM m/p-Akt), similarly to COS7 cells, and a tiny reduction in the [Ca2+] flow through the IP3-gated channels (Vmax: 19.39±0.97 μM/s control versus 17.49±1.34 μM/s m/p-Akt).
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Mr. Kobach won his primary in the governor's race by just 350 votes and is now in an extremely tight race against Laura Kelly, a Democrat, and an independent candidate, Greg Orman, so even a tiny reduction in participation among Democratic constituencies could put him in the governor's mansion.
The proposal was a major (though not unexpected) disappointment, calling for only a modest increase in fuel efficiency and, by the administration's own testimony, a tiny reduction in oil use -- about 10 billion gallons of gasoline over nearly two decades, or less than one month's current consumption.
Otherwise, with a single IVF cycle costing around £5,000 $$9,890), patients will be unwilling to accept even a tiny reduction in their chance of pregnancy, and so will ignore the risks in favour of returning as many embryos as they can.
And it would be unfortunate if this upsurge of civic virtue resulted in only a tiny reduction in some people's property taxes, an outcome that thwarts the noble motives of those volunteers: to promote civic betterment by reallocating limited resources.
Yet only a tiny reduction in death, if any, has resulted.
The central bank did make a tiny reduction in its effort to prop up the mortgage market.
But the list also demonstrated how even seemingly tough surgery on federal spending programs would produce only a tiny reduction in the budget deficit.
The oceans are steadily warming, and since they currently absorb 50 times more CO2 than is contained in the atmosphere, even a tiny reduction in CO2 absorption by the sea could cause global temperatures to rise significantly.
Moreover, the proposed algorithm could ensure the fairness with only a tiny reduction in throughput performance.
Fear is driving us to spend trillions on achieving a tiny reduction in temperature increases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com