Sentence examples for and a striking decrease from inspiring English sources
Most importantly, this is the first report demonstrating that TAK1 knockdown in an orthotopic model of spontaneous breast cancer metastasis results in a significant reduction in metastasis frequency and a striking decrease in lung tumour burden.
OVs exposed to 3-MA showed a reduced size and a striking decrease in phospho-histone 3, a read-out of the G2/M phase, whereas BrdU incorporation showed a time-dependent increase.
3) While the data support the conclusion that KD of eEF1A1 causes a ∼2-fold decrease in Hsp70 mRNA and a striking decrease in nuclear export, the case made for eEF1A1 having a role on loading Hsp70 mRNA on polysomes is considerably weaker.
We further confirmed the presence of eEF1A1 at HSP70 locus by ChIP-QPCR… experiments " 3) While the data support the conclusion that KD of eEF1A1 causes a ∼2-fold decrease in Hsp70 mRNA and a striking decrease in nuclear export, the case made for eEF1A1 having a role on loading Hsp70 mRNA on polysomes is considerably weaker.
There was almost complete loss of the proteoglycan peak between 1175-960 cm-1, a marked reduction in the sulphate peak at 1241 cm-1, and the peaks at 1203, 1234 and 1280 cm-1, and a striking decrease and spectral shift to 1644 cm-1 in the amide 1 peak, indicative of denaturation and loss of CII from the matrix, across the whole tissue (Table 1).
To further substantiate this finding, we performed a cycloheximide (CHX -chase assay and found a striking deCHX -chasethe p62 hassayife in cells overexpressing GFP-pandin in SH-SY5Y cells, which can be inhibited by MG132 (found3a and 3B).
On the contrary, histological analyses showed atrophy of the CB, superior cervical ganglion (SCG), and AM, with a striking decrease in TH+ cell number.
A defining feature of ribosome profiling data in yeast (Ingolia et al., 2009) and humans (Reid and Nicchitta, 2012) is a striking decrease in ribosome density with codon position, averaged across the transcriptome.
After 3 days of treatment, both Fadu and JHU022 cells saw a striking decrease in colony forming ability of 51.59% and 47.11%, respectively (P<0.01), as compared with control.
A 14-day administration of 200 mg and 400 mg of the extract and metformin (500 mg/kg) showed a striking decrease (P <0.05) in the expression of the gluconeogenic enzymes - fructose 1,6-bisphosphatase, phosphoenol pyruvate carboxykinase and glucose 6-phosphatase in the liver and muscle compared to the diabetic control.
Removal of either CRX, RAX or NEUROD resulted in a marked decrease in blue opsin, S-antigen, PDE6C and CNGB3 levels; withdrawal of RAX resulted in a marked decrease in expression of blue opsin, and withdrawal of NEUROD resulted in a striking decrease in expression of PDE6C.
