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Indeed, we observed that p38 inhibition in HNSCC cancer cells reduces cancer growth in tumor xenografts and a remarkable decrease in intratumoral blood and lymphatic vessels.
Next, Na+/K+-ATPase specific activity was examined by microcolorimetric assay in isolated stria vascularis capillaries of the control and NE animals, and a remarkable decrease in Na+/K+-ATPase activity in the NE animals was observed (Figure 6D, P<0.01).
The introduction of each of the four siRNA sequences (si FSCN1-1, si FSCN1-2, si MMP14-1 and si MMP14-2) inT.Tn.Tn and TE2 cells led to a significant decrease of the target mRNA and a remarkable decrease in the amount of the target protein.
Another clinical research with postmenopausal women treated by the herb pair (two capsules, containing 1 g water extract/day) demonstrated that the herb-pair treated group has a significant improvement in intima-media thickness and a remarkable decrease in TC and LDL as compared to placebo-treated group after 12-month treatment [ 149].
After 24 h of TTHL (IC80) treatment, approximately 55% MCF-7 cells were in early apoptosis (labeled with annexin V-PE), 15% cells were in late apoptosis (labeled with both annexin V-PE and 7-AAD), and a remarkable decrease was observed in the viable cells population (unlabeled with either annexin-V or 7-AAD) compared with the untreated control cells.
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The magnetic properties of the contained nickel reached a coercivity as high as Hc ≈ 153 Oe and showed a remarkable decrease of saturation magnetization.
Between 15 and 25°C a remarkable decrease in the breakdown potential was observed whereas in the 25 50°C range it remained practically constant.
This delay was correlated with: (i) a strong reduction of spongiosis in the ipsilateral side of the brain by comparison with the contralateral side; and (ii) a remarkable decrease in astrocytic gliosis in the whole brain.
Importantly, this delay was correlated with: (i) a reduction in the spongiosis in the cannula side of the brain which is all the more evident that we are far from the injection site; and (ii) a remarkable decrease in astrocytic gliosis throughout the brain.
The high-aspect-ratio pores fabricated by anodization with an applied magnetic field offer a pore diameter smaller than 30 nm and a remarkable decreased growth of side pores.
The presence of H2 shifts both anodic and cathodic branches to the lower values of current densities and thus causes a remarkable decrease in the corrosion rate.
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