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The neuromuscular phenotype in Sod1 null mice has been demonstrated to be caused by the lack of SOD1 in the mitochondrial intermembrane space and a related decrease in axonal mitochondrial density (Fischer et al., 2011).
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Instead, structurally reduced limbs exhibit abbreviated embryonic expression of the gene sonic hedgehog and a presumably related decrease in the proliferation of limb mesenchyme.
The correlation analysis between the performance data of learning of sound-gesture associations and the BOLD signal revealed a learning related decrease of activity (not deactivation) of left and right BA44 and the l-IPL.
While perceived severity remained stable and perceived vulnerability decreased slightly, there was a stronger decrease in the amount of information received and related decrease in knowledge.
A recent study amongst workers with these symptoms showed a symptom related decrease in the quality of life score of 31% [ 3].
There was a dose related decrease in platelet number, although all platelet counts were within the normal reference range.
Interestingly, the identified learning related decrease of activity in the left and right BA44 and the l-IPL was not related to an increase or decrease in connectivity between these areas.
As expected, immunofluorescence showed increases in E-cadherin and β-catenin and inversely related decreases in EGFR expression in the presence of hepatocytes.
Another possibility is that altered IEG expression is age related, decreased in 3-month-old mice and normal in the slightly older mice used here.
Age related decreases in estrogen lead to disrupted microarchitecture of trabecular bone [ 22].
The mechanism of age related decreases in serum testosterone levels has also been the subject of investigation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com