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We propose a history of "rise and fall," that is, the emergence, expansion and lineage specific loss of this protein family and a rationale of how a complex molecular trait related to mechanoreception became essential in some lineages but redundant in others.
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This elevated expression may, in part, account for the development of serum antibodies, and give a rationale of application of s-MKRN1-Abs as a tumor marker.
These results suggested that HDACi and doxorubicin combinations could be useful for treating patients who recur on existing therapies and provide a rationale of testing this combination in clinics.
When asked what authority he had to break up banks like JPMorgan Chase, Sanders deflected and launched instead into a rationale of why the banks should be broken up.
These findings indicate possible efficacy and a rationale for further exploration of GUT-70 as a new therapeutic strategy for MCL.
The prevailing model will be a more spatially distributed/diffused one, but it will be based on a rationale of specialization and efficiency.
Recent advances had provided insights into how MHC interacted with peptides [14] [22] and a rationale to predict optimal epitopes of MHC-binding [23], [24].
For an environmental care, a good management of waste and a rationale use of paper are needed.
Hence inhibiting the eIF4F checkpoint suppresses tumor growth through multiple mechanisms and provides a rationale for development of broad-acting therapeutics.
By veering away from the original, the film developed a style and rationale of its own -- a change Potter didn't appreciate.
The goal of this study was to explore the scientific evidence and provide a rationale for the use of saliva for systemic disease detection.
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