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In particular, the reduction of HKII levels in response to EGFR inhibition causes a decrease of glucose molecules entering the glycolytic cascade and a parallel reduction of 18F-FDG phosphorylation and tracer entrapment.
Knife wear and the use of a piece breaker determined a marked increase in the incidence of small chips (8 3 mm) and fine particles (<3 mm), and a parallel reduction in the incidence of large chips (45 9 mm).
An increasing incidence of preterm birth and a parallel reduction in infant mortality due to prematurity were observed in Hubei Province from 2001 to 2012.
Notch inhibition in the invasive breast cancer cell line MDA-MB-231 resulted in increased E-CADHERIN expression and a parallel reduction in their invasive capacity.
To the contrary, Notch inhibition in the highly invasive cell line MDA-MB-231 resulted in increased E-CADHERIN expression and a parallel reduction in their invasive capacity.
Corder et al. [ 28] reported an annual increase of 10.6 min/day in ST and a parallel reduction of 3 min/day in MVPA and 9.8 min/day in LPA among 9 10-year-old children.
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Similarly, reducing the oxygen content of the superfusion solution by bubbling it with 95%N2/5%% CO2 led to a rapid decrease in oxygen saturation of the ACSF and caused a parallel reduction in the power of fast network oscillations.
Furthermore, suppression of the CXCL12-CXCR4 axis due to loss of CXCR4 is potentially accentuated by this concomitant up-regulation of CD26, because its DPPIV activity degrades CXCL12 and there is therefore a parallel reduction in the bioactivity of the chemokine ligand as well as the decline in its receptor.
Moreover, REST-null ES cells produced lower levels of Mash1 and Ngn1 expression (P<0.01) and this was reflected in a parallel reduction in the number of Mash1+ NPCs (∼50%) as compared to the control (87%) (P<0.05) (Fig. 2D 2E; Table 1; Fig. S4B and 4D).
Conversely, inhibition of the pathway by overexpression of the dominant negative dnMAML1 produces a parallel reduction in protein and mRNA levels of N-cadherin and α9-integrin.
42 In the present study, residual tumors in mice treated with celecoxib or EP4A showed a parallel reduction of Akt and ERK phosphorylation, concomitant with an increase in apoptotic/proliferative cell ratios.
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Justyna Jupowicz-Kozak
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