The phrase "and a considerable accumulation" is correct and usable in written English.
It can be used when referring to a significant gathering or collection of something, often in a formal or academic context.
Example: "The research revealed that there was a considerable accumulation of data over the years, which provided valuable insights."
Alternatives: "and a significant buildup" or "and a substantial collection".
That said, for those interested in understanding negativity in 2018 it is important to remember that negativity is not new to politics; and that there is a considerable accumulation of research on the nature, relevance and impact of negativity on political behavior, and on behavior more generally.
Consistent with earlier findings in primary cultured cerebellar neurons generated from mice with systemic SPL deletion13, neural-targeted depletion of SPL resulted in a considerable accumulation of S1P and its metabolic precursor sphingosine with no changes in ceramide and sphingomyelin in brains of SPLfl/fl/Nes mice (Fig. 1c).
This might have led to a considerable accumulation of homoplasies and, hence, to an erosion of the phylogenetic signal in the molecular data.
Mitochondrial accumulation was scored for cells that had a considerable accumulation of mitochondria around the nucleus, and mitophagy was assessed by the absence of detectable mitochondrial marker staining.
For example, the loss of function in two parallel DNA-damage repair (tumour suppressor) pathways can lead to a considerable accumulation of DNA damage, resulting in genomic catastrophe and triggering apoptosis in cancer cells, as in the case of BRCA-PARP [ 11].
A considerable accumulation zone for buoyant plastic was identified in the eastern part of the North Pacific Subtropical Gyre17.
Moreover, there was a considerable accumulation of delta 2-tubulin, a modified form of α-tubulin, which indicates the formation of long-lasting, highly stable microtubule cytoskeleton (Fig. 1e, f 22.
The TMA is the second largest urban agglomeration in Greece accounting for more than 1,000,000 inhabitants, with a considerable accumulation of urban traffic as well as industrial activities.
Interestingly, overexpression of MCOLN1 caused a considerable accumulation of GFP-LC3-labeled autophagosomes (Fig. 7B).
In a recent study, a considerable accumulation of the 80 kDa fragment in the extracellular compartment of metastatic prostate tissue has been observed (Kuefer et al, 2003).
