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GOLPH2 has been described as an excellent ancillary tissue biomarker for the diagnosis of prostate cancer [ 20- 22].
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The greater hospital resource use, costs, and complication rates associated with oncologic surgical resections relative to benign indications could be attributed to several differences in the surgical techniques required, extended tissue resection for adequate margins, lymph node dissection for staging, and/or the resection of ancillary tissues [13 15].
Anatomic Pathology specialty training including: dermatopathology, forensic pathology, AP ancillary studies/molecular, tissue hematopathology, bone marrow hematopathology, neuropathology and additional selective block(s).
The high rate of GOLPH2 protein overexpression, which is also seen in AMACR-negative prostate cancer cases, suggests its use as an additional ancillary positive tissue marker of prostate cancer.
At the tip of the sperm head is the acrosome, a specialized sack of enzymes that help the sperm penetrate through what Joseph S. Tash, a male fertility expert at the University of Kansas Medical Center, calls the "forest" of ancillary cells and connective tissue that surrounds the ripe, ready egg.
The enzymatic products of these genes are not usually involved directly in lethality but play ancillary roles in causing tissue inflammation and destruction (further details are discussed below).
Lymph nodes were assessed for their size, shape, internal architecture, echogenicity, nodal border, posterior enhancement, and ancillary features (adjacent soft tissues oedema, and matting).
These data clearly suggest GOLPH2 as an additional ancillary positive marker for tissue-based diagnosis of prostate cancer.
Furthermore, because diagnostic biopsy samples are relatively small, the amount of residual tissue for additional ancillary testing may be inadequate.
To help distinguish melanoma from its imitators, a variety of tissue biomarkers and ancillary techniques (eg, immunohistochemical [IHC] analysis or fluorescence in situ hybridization) are currently available.
Thus, it appears feasible to derive tissue biomarkers that provide ancillary prognostic and predictive information from the study of defined subpopulations of tumor cells.
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