Increased awareness, multiplanar imaging review, and identification of ancillary findings may improve sensitivity for gastroduodenal ulcers.
To write a good SAP for model-based sensitivity and ancillary analyses involves non-trivial decisions on and justification of many aspects of the chosen setting.
The instruments under study provide excellent tools for preparing decisions within the SAP in a transparent way when structuring the primary analysis, sensitivity or ancillary analyses, and specific analyses for secondary endpoints.
Therefore, these Bayesian model selection techniques offer helpful decision support for shaping sensitivity and ancillary analyses in a statistical analysis plan of a clinical trial with longitudinal count data as the primary endpoint.
Writing a good SAP for a model-based sensitivity or ancillary analysis [ 1, 2] involves non-trivial decisions on and justification of many aspects of the chosen model setting.
The decision on the models for sensitivity and ancillary analyses and handling of informative missing data of the large phase III BEMED trial is based on data from a pre-study with a comparable study population, comparable intervention, and same definition of primary outcome (frequency of vertigo attacks).
Study characteristics, summaries of the methods used for sensitivity analyses and ancillary information are given in Tables S2 S10 (available online).
As a sensitivity analysis we performed ancillary statistical testing only including patients with a BML score > 0 at baseline.
The choice of a statistical method that provides an appropriate causal estimand accounting for the ancillary covariate information and a sequence of sensitivity analyses that examine changes in the causal estimand across a range of plausible confounding relationships. .
To provide the best optimal detection at the time of the visit, HPV was offered as an ancillary test to the cytology to increase longitudinal sensitivity with a minimal impact in specificity.
As a consequence, we elaborated a new score to assess whole brain circulation stop and to increase sensitivity for promoting CTA as the preferred ancillary test in diagnosing brain death.
