Sentence examples for ancestry effect from inspiring English sources

For all situations considered, the power of the GLEAM approach increases with the increment of the local ancestry effect size, most rapidly when the effect sizes are smaller and then levels off with larger effect sizes.

The current analytical approach using genome-wide average estimates will control for confounding due to global ancestry but will not control for confounding due to the local ancestry effect because the global ancestry information is obtained from all markers across the genome and may not accurately reflect local ancestry variation.

All of them indicated following phenomenon: the ancestry effect; familial PD results from rare, highly penetrant pathogenic mutation (e.g. E46K, A1442P); multiple variants of low penetrant (e.g. A350V) contribute to the risk of PD and are involved in the etiology of PD.

In prior FSTT literature, small statistically significant differences have almost universally been overemphasized and misinterpreted to reflect sex and ancestry effects when they instead largely encode nuisance statistical noise.

Systematic inflation in the observed statistics would indicate that ancestry effects have not been fully controlled.

The direction of the ancestry effects we uncovered is consistent with associations reported for US Latinas and Mexican women [ 15, 16, 45] for which a higher nuclear European/lower Native American ancestral contribution increased breast cancer susceptibility.

Interestingly, several of these loci showed ancestry effects, e.g. the key SNP in TBX18 may be of particular relevance in African and Latino groups but was not informative in the Caucasian population.

Two models were used for association studies since model comparison showed an equivalent fit (Additional file 8): one accounted for fixed ancestry structure effect (GLM in TASSEL), the other for both fixed ancestry structure effect and random genetic background effect (MLM in TASSEL).

Two models were used: one accounting for ancestry structure effect (with General Linear Model, or GLM in TASSEL) the other for both ancestry structure effect and random genetic background effect (with Mixed Linear Model, or MLM in TASSEL).

When the generalized estimating equations models were adjusted for ancestry, the effect of the rs7665116 genotype on AO decreased dramatically.

In additional analyses, we (1) added possible confounders (differences in ancestry, batch effect, and genotyping platforms) to the model and (2) reran the analyses on dosage scores (in which the uncertainty of imputation is taken into account).