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500 was born, an ancestral version of AT&T was the most valuable company in the United States by a very wide margin, said Jeremy J. Siegel, a Wharton business school professor, the author of "Stocks for the Long Run" and a market historian.
However, we also identified 51 positions in 45 HARs where Neandertals carry the ancestral version whereas all known present-day humans carry the derived version.
Given the above observations, it is possible that the ancestral version of this assemblage had small-molecule binding capabilities.
This ancestral version of the palm domain was already distinct from other RNA and DNA polymerase catalytic domains of the RRM-like fold (Fig. 1).
The class C GPCR-like proteins in the diatoms may also reflect their evolutionary history and represent a more ancestral version of this protein family.
We computationally reconstruct an inferred ancestral version of the network and trace the evolutionary paths in the lineage leading to S. cerevisiae.
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With respect to this analysis, to say that an eagle's wings are designed for soaring is to claim, first, that the ability to soar (as opposed to other kinds of flying) explains why some ancestral eagles had higher reproductive fitness than others and, second, that eagles' wings are better adapted for soaring than were ancestral versions of the wings.
Many old-time diseases are still present today, but fortunately many of them aren't as prevalent or dangerous as their ancestral versions.
Therefore, a C157R mutation could be functionally-significant in protein-protein interactions, and we cannot exclude at this point that protein-protein interactions might differ between the derived and ancestral versions of TRPV6.
This suggests that ancestral versions of this assemblage probably mediated a generic ligand interaction via a similar interface.
By experimentally dissecting successive ancestral versions of the scaffolding protein, Anderson et al. deduced how the molecular complex that it anchors came to control spindle orientation.
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