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They therefore represent convincing models for ancestral Class I and Class II aaRS.
This implied the presence of an ancestral class I/II protein in Bikonta lineages.
In this case, N. equitans probably retained the ancestral class I LysRS that is found in most archaea.
In some strains, the ancestral class II gene has also been lost, suggesting that the eukaryotic gene has completely taken over its function.
This might explain the difference in size of ACBPs, smaller in the proposed ancestral Class I and larger in the other classes.
Moreover, the ancestral class I/II protein present in LECA might have the same biological function as the protein present in all present day Bikonta organisms.
Similar(39)
Reports suggested Theta, Zeta and Omega GSTs as the most ancestral classes.
In addition, the 5,376 concepts in the taxonomy are represented by 39 different ancestral classes.
Our phylogenetic analysis also supported both Theta and Zeta as the ancestral classes in plants (Supplementary Fig. S1).
Members of a class share one or more common features and inherit the class features of their ancestral classes [ 1, 2].
Alternatively, the basal nature of the putative diatom and microeukaryotic class C GPCR sequences may indicate that these sequences represent a separate, possibly ancestral, family of class C GPCRs.
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