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The underlying dimensions of the scale were checked with an explanatory factor analysis using a Varimax rotation and Principal Components Method as a usual descriptive method for analyzing grouped data [ 20].
Mixed effects models are suitable for analyzing grouped data and make it possible to incorporate both fixed effects, which are parameters associated with the entire population and random effects which are associated with individual units (in our analysis the individual units are cohorts of birth).
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However, when analyzing group data (as opposed to individual data points), censoring data below the detection limit may lead to the loss of useful information [ 19].
However, this is unlikely as the distribution of GP IIb/IIIa inhibitor use was the same in the excluded and analyzed groups (data not shown).
No links between NG2 levels and cognitive decline was found in either group and no significant change in NG2 levels were found when comparing males / females or APOEϵ4 carriers/non-carriers within the analyzed groups (data not shown).
We analyzed group data by a one-way analysis of variance (ANOVA), with or without repeated measures, followed by post hoc multiple comparisons using Tukey's honestly significant difference test when significant main effects of Pb were found (KaleidaGraph; Synergy Software, Reading, PA).
A binomial model, handling the number of tests performed and therefore the implicit maximum, appears more adapted to analyze grouped binary data.
Basic statistics were used to analyze our grouped data.
Figure 3 Rationale for using a joint colour scale instead of single scales for analyzing groups of data.
The same cut-off as in [ 16] (high hypochondriacal group > 1) and the Mann–Whitney- U test for analyzing group differences independent of data distribution were applied.
The GIFT toolbox is especially designed to analyze group rsfMRI data, and works in three steps.
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