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Data cleaning, coding and analyzed were performed using the SPSS statistical software.

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Statistical analyze were performed using SAS Software 9.2 (SAS Institute Inc., Cary, NC).

Survival analyze was performed using Cox proportional model with time-dependent covariates to assess the effect of the variables of interest on overall survival.

All analyzes were performed using flow cytometry.

All the statistical analyzes were performed using the SPSS Base 19.0 for Windows (SPSS Inc., USA).

All statistical analyzes were performed using R.

All biochemical analyzes were performed using commercially available kits, according to the Manufacturer's protocols.

Gene expression analyzes were performed using 3 arrays, representing 3 biological replicates with one replicate done in a dye-swap manner to test for dye-based bias.

Statistical analyzes were performed using SPSS version 13.0.

All statistical analyzes were performed using the SPSS version 17.0.

Analyzes were performed using GraphPad Prism version 4.0 (GraphPad Software, San Diego, CA, USA).

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