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As a proof of concept, the wild-type and two engineered strains analyzed were consistent with published experimental results.
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Our finding that elevated expression of PTK6 transcript correlates with adverse outcomes for patients with breast cancer in all cohorts analyzed is consistent with a recently reported correlation between PTK6 mRNA levels and tumor grade based on analyses of 44 tumors [31].
Moreover, the expression patterns at 48 h of the genes analyzed was consistent with direct or indirect regulation of those genes by ex-siRNAs of different classes.
The apparent absence of O-mG adduct formation in vitro by microsomes from any of the mouse tissues analyzed was consistent with the fact that N-mG was much more abundant than O-mG in vivo, in AOM-treated mice (Table 1), which has been noted previously with adducts formed by another compound.
The higher expression of mFwe transcripts in tissues such as eyes and brain (supplementary material Fig. S1A D), as compared with their abundance in the rest of the tissues analyzed, is consistent with the described expression and function of dFwe in the Drosophila nervous system (Yao et al., 2009).
Similarly, the strong and specific staining for miR-143 and miR-145 in the iris sphincter at all developmental stages analyzed is consistent with recent reports that demonstrate the key role of these two miRNAs in modulating smooth muscle cell proliferation and differentiation [ 46].
Home-cage circadian rhythmicity measured by assessing heart rate, core body temperature and locomotor activity in wt mice analyzed in this study were consistent with previously reported data (Gaburro et al., 2011; Sanchez-Alavez et al., 2011).
The moisture contents of the analyzed samples were consistent with previously reported values of honey samples from Bangladesh of 12.79% to 22.32% [ 17].
Basic cytogenetic data, including the diploid number and the chromosomal morphology of the analyzed species, were consistent with previously published information [24, for review].
When only cycles with autologous embryos were analyzed, the clinical outcomes were consistent with the main analysis.
The VA results in the patients analyzed in this subset were consistent with the entire cohort (Kaiser et al. 2007).
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