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This hypothesis must be qualified, however, given the small number of animals analyzed in both studies.
Brain autopsy material used in the present and Liu et al. [14] studies was partially obtained from the same source (Tissue Resource Center, University of Sydney); only two of all subjects were analyzed in both studies.
One reason might be the different identity of the HCC cell lines analyzed in both studies.
We also compared the ERα and E2 levels within the nine melanoma cell lines analyzed in both studies.
There were 164 peptides analyzed in both studies, 77 peptides only analyzed in this study, and 9 peptides only analyzed in the prior study.
Thus, the expected number of genes upregulated in both studies could be computed as a product of the corresponding proportions and the total number of genes analyzed in both studies.
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If N1,2 were the number of genes analyzed in both study 1 and study 2, Pu1 and Pu2 would be the proportion of genes upregulated in studies 1 and 2, correspondingly.
This was possible, since seven inbred lines (P033, P048, S028, S036, F039, F047, L024) were analyzed in both independent studies.
However, comparison of the results obtained for two offspring analyzed in both our studies showed that different genotypes identified might come from the different types of clinical materials used as well.
Although the prevalence rates are similar, it should be noted that the definitions of "contact" varied considerably between the studies analyzed in both meta-analyses.
Among the 62 proteins analyzed in both this study and by Ortiz et al. 13 are identified as being under positive selection in the Ortiz et al. study.
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