The different activity level of the three lesions and a potential sampling bias, since we can only analyze a fraction of the infiltrate, most likely underlie this TCR heterogeneity.
In the present study, due to practical cell culture limitations, we only analyzed a fraction (n = 72) of patients in the previous study (n = 274).
Although their underlying mechanisms have been extensively analyzed, only a fraction of the potential molecular components have been identified.
Since we have quantitatively analyzed only a fraction of the total number of volatiles present in the urine, one can argue that we have missed the critical components, which are controlled by and consequently would segregate with the MHC.
In most analyzed genomes, a fraction of SLSs could be grouped into clusters, containing at least 7 non-overlapping elements.
To control over stimulus and performance confounds, we capitalized on the blindsight phenomenon and selectively analyzed a large fraction of trials with identical stimuli and accurate responses, which differed only in subjective reports of seeing or not seeing the stimulus.
It is noteworthy that we were able to analyze only a fraction of the promoter sequences, mainly due to alternative promoter usage and the poorly annotated TSS information available.
Therefore we conclude that by using our approach we are able to analyze a synchronized fraction of newly formed heterocysts, which enabled a better detection of proteins involved in the heterocyst specific physiology.
In this study, we detected a strong signal for genetic isolation for subsets of the village populations that could only be discovered by analyzing a representative fraction of the village populations.
Because there is huge growth of the population during the early generations, we can only analyze a small fraction of the potential progeny (we cull the population at each generation).
