Exact(37)
The effects of seven analytical variables including particle size, concentration of glycerol and HNO3 for stabilization and analyte extraction, respectively, the effect of ultrasonic agitation for slurry homogenization, concentration of chemical modifier, pyrolysis and atomization temperature were investigated by a 27−3 replicate (n = 3) design.
And the analytical variables of this method, such as accuracy, precision and interference factors, have been discussed.
It is found that both formulation and analytical variables can contribute to pharmaceutical HPLC assay bias using model compounds and formulations.
The use of a central composite design and the response surface methodology to determine the best conditions allows the optimum combination of analytical variables (pH, NaCl and extraction time) to be identified.
The analytical sample also excludes individuals with missing information in other analytical variables used as controls in the models (remaining N = 63 772).
Missing values on analytical variables have been imputed to the country-specific mean using the dummy-variable imputation method to avoid losing further observations (Allison 2002).
Similar(23)
Underpinning all of these important developments is the need for high quality tissue samples and the impact of pre-analytical variables on tissue research is discussed.
To investigate potential interferences of two pre-analytical variables, the storage time and the vacutainer tube, on the quantification of 20 amino acids using a UHPLC-MS/MS method.
The anti-FXa assay appears to be a better method for monitoring heparin subjects than the aPTT due to the lack of effect of pre-analytical variables.
Furthermore, the differences in pre-analytical variables, such as sample-collecting and storage protocols are also important [130].
The purpose of this study was to determine whether the anti-activated factor X (anti-FXa) assay is less affected by pre-analytical variables in monitoring patients on unfractionated heparin (UFH) and low molecular weight heparin (LMWH) than the activated partial thromboplastin time (aPTT).
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