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To assess analytical imprecision and comparability of red blood cell distribution width (RDW) on Abbott Sapphire, Mindray BC6800, Siemens Advia 2120 and Sysmex XE-5000.
However, an indicator based on measurement at multiple time points, calculation of slope, and relation of slope to a binary cutoff may be subject to effects of analytical imprecision and sampling time variation.
A request to report laboratory values to a specific number of decimal places represents a delicate balance between clinical interpretation of a true analytical change versus laboratory understanding of analytical imprecision and significant figures.
Moreover, it does not seem that the intra-method analytical imprecision contributes to these differences, since the precision performances declared by the individual manufacturer are essentially overlapping (Table 1).
Moreover, analytical imprecision seems not contribute to the above differences, as the values declared by the individual manufacturer were essentially overlapping (although obtained with different protocols, some of them standardized, some others not) and in general lower than 10% for both intra- and inter-assay imprecision (Table 1).
We used quality control procedures to investigate analytical imprecision and inaccuracy.
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The total variation observed is composed of preanalytical variation, analytical variation (imprecision and bias), and inherent within-person biological variation.
No indication of the comparison method's analytical performance, bias, imprecision, total error [ 8], or its traceability to higher reference methods is provided.
Data regarding the biological variation and analytical quality specifications (imprecision, bias and total error) for judging the acceptability of method performance for oxidative stress biomarkers in urine are conspicuously lacking in the literature.
Selectivity, sensitivity, linearity, intra-assay imprecision and analytical recovery, extraction efficiency, matrix effect, process efficiency, hydrolysis, and drug carry over were evaluated.
Details regarding assay imprecision and analytical sensitivity have been published [ 24].
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