Individual components should also be selected on the principles of analytical soundness, comprehensiveness, pertinence to the measured phenomenon, and also relationship with other individual components (OECD 2008).
Although we are in the process of completing a formal software comparison project, we are confident that the MIX program can compete in many respects (usability, analytical options, comprehensiveness, and export options) with most of the existing meta-analysis programs like Comprehensive Meta-Analysis [ 28], MetaWin [ 38], RevMan [ 39], or WEasyMA [ 40].
Recent studies have used bioinformatics approaches, such as biological networks [ 27], to complement the existing experimental approaches to increase the comprehensiveness of proteome coverage and enhance analytical resolution.
Development of new analytical techniques is largely focused on increasing resolution and comprehensiveness, increasing speed and throughput of analytical assays and equipment miniaturization.
The lack of theoretical background or sound analytical approach for the choice of specific components compromises the indicators' comprehensiveness.
In particular, new instrument configurations, new quantitative approaches and optimized software tools to analyze MS-derived proteomic data have largely improved the analytical performance of MS-based proteomics, in terms of reproducibility, dynamic range, limit of detection (LOD), comprehensiveness and quality of the results [7,9,22 24].
The comprehensiveness is more problematic.
That comprehensiveness can be a problem, though.
The comprehensiveness of the agreements exceeded expectations.
