Sentence examples for analyte instability from inspiring English sources
Identifying a sensitive and specific biomarker for diesel exhaust is not an easy matter, however, since any candidate needs to be associated with a well-vetted and suitably validated analytical method that is free of the inaccuracies caused by matrix effects, analyte instability, or chemical interference (Calafat and Needham, 2008).
Sample preparation is an important part in the pharmaceutical impurity analysis,because matrix effects in trace analysis were enlarged, causing loss of sensitivity,abnormal recovery, and analyte instability.
Unfortunately, we were not able to accurately quantify α-hydroxytamoxifen, partly because of analyte instability.
Conjugated hormones do not seem to be a major EDC of concern here, which is consistent with previous data from swine sow AFOs; however, given the accumulation of E1-3-S in the solid phase of the lagoon, the potential underestimation of E1-3-S because of analyte instability prior to extraction should not be discounted.
We suspect that loss of platinum analyte due to the instability of oxaliplatin and its reactivity with blood components during the delayed processing of blood samples may have contributed to invalid plasma platinum concentration measurements in their study, although it is not possible to be certain about this.
Another source for poor method performance of these few analytes might be the instability of the QC-material suspected in 1 level in this study due to trend for decreasing values in results over time.
The sporadic instability observed with other analytes may be caused by biological variables – such as disease stage, age or treatment regimen – additional to the duration of storage at −80°C.
Combining the preparation of external standards with matrices similar to the sample material with the use of an internal or pseudo-internal standard can counteract the matrix-related effects on the material ablation, aerosol transport, and analyte ionization, as well as that of instrument instability and/or signal drift.
In the first step of this analysis, we eliminated analytes that exhibited unexpected variation compared to internal controls, due to, for example, sample instability.
"Widespread instability".
