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Three-dimensional gait analysis will be measured by the Gait Analysis Process (OrthoTrak 6.6.1 and Foot 3D 1.0).
Health benefits for the economic analysis will be measured in terms of quality adjusted life years (QALYs).
Plasma glucose, lipid profile, HbA1C, albumin, electrolytes, and urine analysis will be measured in the next morning.
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Within the cost-utility analysis, outcomes will be measured by means of the standard Dutch version of the EuroQol (EQ-5 D [ 24].
In the cost-utility analysis, primary outcomes will be measured in terms of quality-adjusted life years (QALYs) gained.
In this analysis, the outcome will be measured as "difference scores" (the 1 week knowledge score subtracted from the three month knowledge scores) using linear regression with GEE and adjusting for unequally distributed baseline characteristics [ 54].
Therefore, for the purpose of the cost-utility analysis, at-work productivity will be measured using the Work Productivity and Activity Impairment – Specific Health Problem (WPAI-SHP) scale [ 39].
Many studies have been carried out to predict the density of electrons and the distribution of the major positive ions, but there is no recent analysis concerning the electrical conductivity that will be measured by Huygens.
The study will use an intention-to-treat analysis and the main outcome variable will be measured at the beginning of the study for each participant.
Changes in health related quality of life over time, and differences between the two groups will be measured using analysis of variance.
The first step is to select peptides from the target proteins that will be measured using MRM analysis.
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