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value is expressed in terms of the zero time-lag covariance matrix of the loads, which in most applications of structural analysis will be calculated from frequency-domain, stress-component transfer functions and the cross-spectral density matrix of the applied loads.
Results of our main analysis will be calculated with Cox proportional hazards models, with adjustment for five pre-specified baseline covariates.
The analysis will be calculated using the indirect standardisation method.
Multivariate analysis will be calculated with multiple linear regression and logistic regression models.
Further, inter- and intra-assay coefficient of analysis will be calculated for all of the measurements performed.
Health economic analysis will be calculated as the sum of hospital cost (inpatient, day care and outpatient care), use of general physician and primary healthcare (rehabilitation, nursing homes, home care, etc).
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In the primary analysis these will be calculated using linear models that include baseline values of outcome variables as covariates to maximise precision.
In the cost-analysis, direct costs will be calculated 'ing to the medication-derived costs those derived from the use of sanitary services (visits to Primary Care, Specialized services and Emergencies, as well as hospitalizations).
For all outcome measures, a within subject repeated measures analysis of covariance (ANCOVA) will be calculated to determine significant changes over time between groups.
Statistical analysis plan: Descriptive statistics will be calculated as percentages for discrete variables, and median with IQR or mean with SEM for continuous variables, as appropriate.
The statistical analysis of the two primary endpoints will be calculated based on the full analysis set to prevent from an overoptimistic estimate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com