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Data collection and analysis were performed by an independent examiner (other than restorative dentist and surgeon).

All writing, program design, simulation runs, and analysis were performed by Marshall Abrams.

Data collection and analysis were performed by an independent clinical reviewer.

The probabilistic uncertainty analysis were performed by using Monte Carlo simulations.

Data acquisition and analysis were performed by the CellQuest program (Becton Dickinson).

DNA content and cell cycle analysis were performed by flow cytometry.

Haplotype-based association analysis and conditional analysis were performed by the WHAP program [36].

Student's t-test, ANOVA, Tukey's test and correlation analysis were performed by GraphPad Prism 5.0 software.

Stimulus generation, data acquisition and analysis were performed by Matlab interface BIOSYST [22], [24].

Data analysis were performed by Patchmaster-Software (HEKA electronics) and Igor Pro (WaveMetrics, Oregon, USA).

Physical examinations and bioimpedance analysis were performed by trained research nurses.

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