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Imaging data acquisition and analysis were accomplished using Aquacosmos 2.6 software (Hamamatsu Photonics).
Instrument control and data acquisition and analysis were accomplished using Xcalibur Version 1.4 software (Thermo Scientific, Waltham, MA).
Microscope control and image capture and analysis were accomplished using the Slidebook™ image acquisition and analysis software package (Intelligent Imaging Innovations, Inc., Denver, CO).
Data acquisition and analysis were accomplished using pClamp10.1 (Axon Instruments) and custom software.
Voltage control, data acquisition and analysis were accomplished using custom software.
Patch pipettes (2 5 MΩ) were pulled from borosilicate glass, and data acquisition and analysis were accomplished using pCLAMP 8 software (Molecular Devices).
Spatial density analysis is accomplished using a PERL script (see Additional file 1).
The heavy metal analysis was accomplished using atomic absorption spectrophotometer (AAS) (Brand Varian Spectra 55B).
The electrochemical analysis was accomplished using a rotating ring-disk electrode.
Probabilistic stability analysis is accomplished using statistical parameters and probability density functions for each discontinuity parameter.
Morphologic characterization was done by scanning electron microscopy (SEM), while the structural analysis was accomplished using X-ray diffraction and Raman spectroscopy.
