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To demonstrate that this correlation was not an artifact of our analysis, we randomized the annotation of disease genes.
As a further test of the significance of this GO-term analysis, we randomized the microarray data sets by randomly reassigning gene names to the microarray gene expression p-values (see methods), and we asked whether these would yield any specifically enriched GO-terms that were also found in the non-randomized data set.
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In an association analysis, we simply randomize the sample labels of to assess the significance of the summary score.
To test this hypothesis, we performed the same analysis by randomizing the pairings between viruses and their hosts.
To simplify the phylogenetic analysis, we generated two sequences by randomizing the SNPs of humans and chimpanzees respectively to represent their RHOXF2 coding sequences.
One trial was randomized by compound, but for the analysis we assumed that it was individually randomized (Greenwood 1989 GMB).
Observers were blind to the period, the journal, the authors, the method (meta-analysis, randomized, non randomized), and the methodological quality from which each conclusion was derived.
The first control analysis of "Randomize sites", which randomizes the order of polymorphic sites before analysis, detected no gene conversion event in horse, rat, mouse and guinea pig datasets, implying the results of subsequent GENECONV analyses are reliable.
The analysis included all randomized patients who received the study drug (full analysis population).
This study was a secondary analysis of the randomized, controlled study conducted by Ylinen et al. [ 23].
METHODS: Patients harboring a recurrent glioblastoma multiforme that reacted with the antitenascin mAb 81C6 during immunohistochemical analysis were randomized to receive an intratumoral injection of the human-murine chimeric mAb Ch81C6, which had been labeled with the 123I tracer.
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