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The survival analysis was finalised in May 2011 after 416 patients had died.
Common themes were discussed between the two investigators before the data analysis was finalised.
The code was sealed by an independent monitor and was not broken until the statistical analysis was finalised.
The statistical analysis plan for the pooled analysis was finalised prior to unblinding of results from the ASCEND study.
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The trial statistician will remain blind to allocation until full analysis is finalised.
The analysis plan was finalised before the trial was unblinded.
The analysis plan was finalised prior to preparation of the endpoint dataset (http://www.addition.au.dk/, accessed 10 July 2013).
Cartilage loss or joint space narrowing (JSN) were not assessed by MRI as the statistical analysis plan was finalised before a JSN assessment method was added to the RAMRIS method.
The equal status of the two primary outcomes was agreed at a meeting of the Trial Steering Committee on the 21st January 2005, where the analysis plan was finalised prior to completion of trial data collection.
All analyses were described in a statistical analysis plan (SAP) which was finalised prior to initiating any analysis.
The analytical plan was finalised before the analysis was undertaken.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com