The analysis was executed using the DMU Package [26], [27].
Principal component analysis was executed using in-house software written in Matlab [The Mathworks, Inc., Natick, MA] based on the algorithm described in Alexander and Moeller [ 31].
Statistical analysis was executed using Kyplot 2.0 beta 15.
The GSEA was executed using the GSEA 2.0 software package (Broad Institute of MIT and Harvard, Cambridge, MA, USA).
All assembly software was executed using the default parameters.
Statistical analyses were executed using the Data Processing System software v11.0.
Statistical analyses were executed using the SPSS 20.0 software.
All data analyses were executed using the SPSS Version 21.0 software.
The numerical simulation was executed using ABAQUS software, and the predicted results were in accordance with the experimental data.
Additionally, the Kruskal-Wallis test was executed using Multi Experiment View (V.4.9) software to determine the significant metabolites.
Peptide synthesis was executed using a CEM Liberty microwave peptide synthesizer (Matthews, NC) and PepDriver software.
