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In conclusion, the cost-utility analysis using a novel model reflecting evidence-based clinical pathways demonstrated that the high efficacy of palivizumab prophylaxis compared to no prophylaxis resulted in a substantial number of prevented hospitalizations and generated a high number of QALYs gained.

We compared them with a control group (n = 10) without any shoulder pathology and measured shoulder movement by 3D motion analysis using a novel 3 D model.

However, in a multi-metric analysis using a novel Bayesian mixture model developed to deal with correlated variables this finding was not confirmed with no single factor being associated with an important increase in risk.

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Details of the western blot analysis are described in Additional file 3. To achieve maximum coverage of the membrane proteome and N-glycoproteome in a reasonable time, we performed a novel proteomic analysis using a combination of crude membrane (CM) fractionation and protein digestion strategies without extensive peptide fractionation.

Analysis using a disease-oriented ontology revealed that novel lncRNA neighborhoods are enriched with lymphoma or other immune cell malignancy genes (Fig.  4b).

Moreover, we envisage the possibility to perform single cell or tissue analysis by using a novel implemented microscope for dual color bioluminescence imaging [22], [23].

The Koiter Newton method has been proved to be a computationally efficient method for buckling and post-buckling analysis of structures, using a novel reduced-order modeling strategy.

Integrative computational analysis was performed using a novel Tree-guided Recursive Cluster Selection (T-ReCS) [1] algorithm to select the most informative features/genes, followed by TargetScan miRNA target prediction (Human v6.2) and mirConnX [2] for network inference.

Using a novel analysis tool, Network-Based Diffusion Analysis (NBDA), we were able to directly test the predictions of 2 hypotheses, acquisition of novel behavior due to social or individual learning.

However, using a novel analysis, which allowed us to adjust for both the smoking status of an individual's friends and the concordance for friends' smoking status within pairs, we found greater concordance for smoking in MZ pairs only at wave 1 when most twins were living together.

Sequence feature information in BioMuta is collected not only from COSMIC (36), ClinVar (http://www.ncbi.nlm.nih.gov/clinvar/) and UniProtKB (14) but also through active biocuration from publications and automated analysis of NGS data from sources such as TCGA using a novel data analysis platform HIVE (High-performance Integrated Virtual Environment) (37, 38).

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