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This is achieved by minimizing an objective function that includes a quadratic error term added to a regularization term that considers a priori beliefs or data-driven analysis to induce group sparsity [35, 36, 38].
If cells were cultured in galactose for 24 h prior to analysis to induce dependence on mitochondrial respiration, MPP+ reduced cellular ATP concentrations, and this effect was also rescued by U0126.
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Afterwards, we used InnateDB and pathway enrichment analysis to identify induced host pathways [ 52].
Genes that exhibited such an expression profile belong to the aforementioned categories of genes found by RNA-seq analysis to be induced during microsclerotial development (Additional file 4) – namely, pigment biosynthesis and secondary metabolism genes, transcriptional regulators, and hypothetical genes.
We use Semantic Query Expansion (SQE) and Formal Concept Analysis (FCA) [ 4] to induce a lattice of concepts over hundreds of ontologies and terminologies at once and to find the best-matching concepts.
In particular, the silylation step, which is required to make the samples volatile for the GC-MS analysis, has been shown to induce oxidation of normal bases at the level of about one oxidized base per 10(4) normal bases.
This analysis explores alternative policies designed to induce a transition to a more efficient energy system by immediately deregulating industrial fuel prices, gradually deregulating fuel prices, and introducing investment credits or feed-in tariffs.
Importantly, two catalytic mutants of CENP-V designed based on this predicted structure were shown by a novel pattern recognition analysis algorithm to be unable to induce chromatin hypercondensation in a pattern similar to the wild-type protein when overexpressed in HeLa cells.
Both NFKB1 and NFKBIA have previously been shown by microarray analysis to be significantly induced in polyA mRNA between 3 4 hrs following phorbol or lectin activation of either Jurkat or human peripheral blood lymphocytes [ 7, 8, 11, 17].
Ten genes were shown by microarray analysis to be strongly induced in strain Dvd-T5 during microsclerotia development.
As the circulating miRNAs could exert post-translation regulation in the target tissue, we preformed the miRNA and mRNA integrated analysis to describe statin induced miRNA function related to vascular disease.
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