Forte et al. performed the grade-of-membership analysis in 490 type 2 diabetic and 349 control subjects of Italian Caucasians [ 14].
Ten clinical variables included in factor analysis were the grade of spasticity, dystonia, choreoathetosis, hypotonia, mobility, upper extremity/hand function, expressive language, feeding/swallowing difficulty, endocrinopathies, and temperature dysregulation.
Hence, a detailed analysis of the grading of RCTs was suggested [ 59].
In the multivariate analysis, only the grade of malignancy was associated with the presence of AT2 (HR 3.4; 95% CI, 1.08 10.86; P=0.036).
Overall quality of evidence was assessed based on study quality, results from sensitivity analysis, and principles of the grades of recommendation, assessment, development, and evaluation (GRADE).
For the statistical analysis, the six grades of staining were reduced to three grades: negative, [0/]; I, moderate ; and II, intense.
Further validation of the methodological quality of individual randomised controlled trials, rating the quality of evidence and strength of recommendations of this meta-analysis, used the grading of recommendations assessment, development, and evaluation (GRADE) system, 25 as recommended by the Cochrane Collaboration.
From the analysis, different grades of malignancy correspond to different structural patterns as well as to apparent textures.
The first typology was constructed using constant comparative analysis; the second relied on the grade of membership (GOM) technique.
ROC analysis will be performed for the grading of the size of levator defects with 3D ultrasound.
