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This analysis should be explained more clearly in the Methods.
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1) The rationale underlying the analysis approaches should be explained more clearly: In the Introduction: "We hypothesized that RATN theta phase alignment may provide the mechanism by which RATN synaptic modification required for memory formation occurs…".
However, several substantive concerns were expressed by the reviewers: 1) The rationale underlying the analysis approaches should be explained more clearly: In the Introduction: "We hypothesized that RATN theta phase alignment may provide the mechanism by which RATN synaptic modification required for memory formation occurs…".
However, several points require further explanation or clarification as detailed below: 1) The authors should clarify the methodology used to identify serotonergic neurons; namely the "light-evoked energy" analysis in Figure 2B should be explained more thoroughly, as it is not a standard method.
Although most studies included in this analysis reported consistent results, 9 17 the pooled estimates should be explained with caution.
It should be explained to the parents that there may be asymptomatic/presymptomatic results with array CGH analysis, and they should be allowed to decide whether they wish to be informed of these findings or not [ 10].
Extraordinary awards should be explained to shareholders.
It should be explained to people.
That should be explained up front.
This should be explained.
Such differences should be explained.
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