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As evident in our analysis, regimen comparisons will depend on the outcome metrics used.
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In a pooled analysis, this regimen has significantly improved survival as part of a chemoradiation regimen or as maintenance combined with chemoradiotherapy when compared with treatment with surgery alone or surgery plus adjuvant radiotherapy.
All enrolled patients were included in the intention-to-treat analysis of regimen efficacy.
It is important to stress the virtual character of this analysis; a regimen was considered adequate when all relevant pathogens isolated in one patient were susceptible to at least one of its components.
52 In another analysis, immunosuppressive regimens containing sirolimus had a risk of death that was 1.33-fold to 1.75-fold higher compared with other agents.
For the meta-analysis, 26 regimens were included in the platinum group and 6 regimens in the non-platinum group.
Since STR is not the only available therapeutic alternative, it was deemed necessary to carry out a comparison with other antiretroviral regimens; therefore the analysis considered the regimens recommended, to a varying extent, by the Italian guidelines.
This applies for first-line therapies as well as for following regimens considering we pooled all data of CSH patients together for the analysis of ART regimens, and therefore regimens after first-line therapy naturally had a greater impact.
For the analysis of ART regimen in the CSH we separated mainly used regimens and minor regimens.
Differences by treatment (multiple daily injections versus insulin pump therapy versus conventional regimens) were to be explored in subgroup analysis but treatment regimen was not reported in most of the studies.
Stratifying the analysis by dosing regimen did not reveal any important differences in efficacy between the two regimens (Analysis 3.1 to Analysis 3.6).
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