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Analysis populations were 'all headache episodes' and those with 'severe pain at baseline'.
For the MIRU-VNTR analysis, Populations 1.3 was used to generate a distance matrix and a phylogenetic tree using the Nei distance [63].
In this analysis, populations were reduced to individuals from the single, most dominant genetic cluster in that habitat (as indicated by the STRUCTURE results).
Both patient allocation to the different analysis populations and assessment of the primary end-point were made by staff blinded to the treatment assignment and before availability of the PCR results.
The fulfilment of the non-inferiority criterion on all analysis populations and the confirmation that in this study the comparator treatment had the expected efficacy [12], [21] proved that DHA-PQP is non inferior to AL in treating African children aged 6 59 months with uncomplicated malaria.
There are 3 analysis populations planned.
Table 5 shows the study analysis populations.
The analysis populations were as follows.
Two analysis populations were defined for this study.
Three analysis populations will be used in this study.
Analysis populations are defined in Supplementary Table 1.
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