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Statistical analysis (one way ANOVA) demonstrated a significant difference between the groups on the binocular accommodative facility test (p < 0.01 Cohen's d = 0.68).

A subgroup analysis, one way sensitivity analysis, and probabilistic sensitivity analysis were also carried out.

Statistical analysis (one way ANOVA) was done with SPSS version 12.

Data analysis: one way Anova followed by Bonferroni's multiple comparison test (*** p < 0.001, ** p < 0.01).

This was confirmed by statistical analysis (one way ANOVA (p > 0.05).

Spot boundary detection, pixel intensity quantification and statistical analysis (one way ANOVA) were performed with the built in TIGR MeV tool.

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Therefore, if a meta-analyst is concerned about the effect of re-randomization on the meta-analysis, one way to sidestep the issue and still obtain reliable results is to use risk ratio as the measure of interest.

We also show that in our model the risk ratio remains constant during the re-randomization, and therefore, if a meta-analyst is concerned about the effect of re-randomization on the meta-analysis, one way to sidestep the issue and still obtain reliable results is to use risk ratio as the measure of interest.

Statistical analysis (One-way ANOVA) was performed using GraphPad Prism 6 on data corresponding to three technical repeats of three independent biological samples.

To answer the question if the treatment-related improvement depends on age, BMI, and testosterone level at baseline, we run a stratified analysis (one-way analysis of variance).

For statistical analysis, one-way analysis of variance (ANOVA) was used, and Scheffe's test was used for intergroup comparisons.

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