Sentence examples for analysis of this modification from inspiring English sources
Here we report the genome-wide analysis of this modification by chromatin immunoprecipitation (ChIP) coupled to massively parallel DNA sequencing (ChIP-seq).
The O-phosphorylation of serine, threonine and tyrosine residues has been extensively studied, since the high stability of O-phosphorylated products has permitted the analysis of this modification with many different techniques [ 1], especially MS [ 2, 3].
After recombination and the necessary crosses to obtain His C /+ heterozygous transgene-bearing flies, we investigated whether H3 K27R expression has any effects that would preclude the functional analysis of this specific modification site.
Fortunately, several new technologies have emerged to assist in identification and analysis of these modifications, shedding new light on an important layer of proteomic complexity.
Further studies involving a larger randomized patient cohort, as well as analysis of the effect of this modification on specific coagulation markers such as tissue plasminogen activator and fibrin D-dimer, are planned.
Consequently, analysis of this important post-translational modification with mass spectrometry (MS) is a central piece in the proteomics toolbox.
Analysis of further modifications of this region (Figure S1) showed the transmembrane domain to be necessary, but not sufficient, for sorting and that almost complete sorting could be obtained using as little as the 83 aa peri-membrane region (aa 891HNNG to ESLW973: construct 18 in figure S1).
MphI and MphK both phosphorylate telithromycin but also phosphorylate azithromycin (Supplementary Fig. 5, Supplementary Table 3), suggesting that resistance phenotype may not correlate with biochemical analysis of drug modification.
Liquid chromatography coupled with mass spectrometry (LC-MS) is the method of choice for analysis of covalent modification of DNA.
