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Efforts to understand the molecular determinants of amyloid formation for AL proteins could only be conducted in a large basis using sequence analysis of the subtypes in a separate fashion since κ and λ protein sequences do not share a large sequence identity.
The follow-up analysis of the subtypes showed a significant interaction effect between Group, Segment, and Lag (F(48, 2880) = 1.39; p <.05), which was not confirmed by the multivariate analysis.
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Analysis of the subtype-specific ligand receptor interactions allowed identification of the major determinants of ligand selectivity, which may facilitate discovery of more efficient drug candidates.
This study represents an in-depth analysis of the subtype diversity of HCV in Venezuela.
Full genome analysis of the subtype B strains did support the distinct clustering of the subtype B Caribbean sequences separate from those from the pandemic, including South America.
This study represents an in-depth analysis of the subtype diversity of HCV in Venezuela, which is still unexplored in the Americas and deserves further studies.
Phylogenetic analysis of the subtype H9N2 viruses showed that they are reassortants possessing 3 gene segments related to subtype H7N3; the remaining gene segments were from the subtype H9N2 G1 clade.
Although previous evidences have implicated the entry of CRF01_AE into China with concurrent epidemics in neighboring countries [7 10], there has been no comprehensive analysis of the subtype's origin in China due to limited samples of those studies.
We performed a functional analysis of the subtype signatures using Signaling Pathway Enrichment using Experimental Datasets (SPEED) [ 45], and enrichment analyses on the Molecular Signatures Database (MSigDB) [ 46], and KEGG [ 39] and Pathway Interaction Database (PID) [ 47] using BioMyn [ 48].
Sequence analysis of the subtype specific sequences of EL1 revealed similarities between GPRC5A and GPRC5D (conserved proline residue at the C-terminal end of the loop) and marked differences reflected by the loss of charged amino acids in GPRC5D (present in GPRC5A/D and GPRC5A).
Given the small number of samples in the subgroup analysis of the clinical subtypes, we have compared the prevalence of 19q12 amplification in ER-negative/HER2-negative ER-negative/HER2-negative ER-negative/HER2-negative, which confirmed a significance association between 19q12 amplification and ER-negativs/HER2-negathee breast cancers (P = 0.0024).
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