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Moreover, Kaplan-Meier analysis of the prognostic value of immune checkpoint molecules revealed that expression of ICOS was positively correlated the clinical outcome of patients with LUAD.
The present study was a retrospective analysis of the prognostic value of BRCA1, RRM1 and RRM2 mRNA expression in NSCLC patients treated with first-line gemcitabine plus docetaxel.
These observations should have important implications for the analysis of the prognostic relevance of B-RAF and N-RAS mutations as well as the development of therapeutic strategies to treat this life-threatening disease [17].
Multivariate analysis of the prognostic factors was performed using the Cox regression model.
Multivariate analysis of the prognostic factors was performed using Cox's proportional hazard model.
We also performed a sex-specific analysis of the prognostic impact of Piwi-like mRNA expression in patients with STS.
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The results of multivariate analysis on the prognostic factors are shown in Table 2.
This database enables systematic meta-analysis of the prognostic value of a gene in multiple datasets and consequently will accelerate cancer research.
A meta-analysis of the prognostic value of blood NLR on clinical outcome in solid tumors showed that high NLR was associated with shorter survival [ 26].
9 14 Messenger RNA (mRNA) data assessing MUC5B as a prognostic biomarker is available at PrognoScan, a database for meta-analysis of the prognostic value of genes using microarray data deposited to the public domain.
Nor did we perform a meta-analysis of the prognostic accuracy of the various individual prognostic factors, since we expected substantial heterogeneity between the primary studies, for example in the number and type of covariates that were studied and, more importantly, in the predictors that were included in a multivariable adjusted analyses (if done) [ 14, 15].
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