Sentence examples for analysis of the prion from inspiring English sources

Full sequence analysis of the prion protein gene was performed using established methods [ 13].

Analysis of the prion protein gene indicated a P102L mutation coupled with valine at the polymorphic codon 129 in the mutant allele, confirming a diagnosis of Gerstmann-Sträussler-Scheinker syndrome (GSS).

In any case the algorithm could be easily adapted to take into account of this particular possible diagnosis and as well as performing immunohistochemistry fresh tissue could be sent for analysis of the prion proten subtypes [ 28, 29].

We annotated numerous conserved genomic elements which are potential cis-elements, deduced 42 new protein primary structures, performed phylogenetic analysis of the prion genes, and showed that the entire PrP conformationally plastic region is conserved between eutherian PrPs and Shos.

We made use of the present availability of vertebrate genomic sequences, and we have conducted the most comprehensive comparative genomic analysis of the prion protein gene PRNP and its homologues, shadow of prion protein gene SPRN and doppel gene PRND, and prion testis-specific gene PRNT so far.

Interestingly, deletion analysis of the CPEB3 prion domain uncovered a tripartite organization: two aggregation-promoting domains surround a regulatory module that affects interaction with the actin cytoskeleton.

In contrast, Western blot analysis of the porcine prion generated through the inoculation of atypical scrapie isolate (SC-PS152) showed a dramatic molecular shift after passage in the porcine PrP mouse model.

Analysis of the glycoform ratios of prion fragments and application of a two-dimensional immunoblot may help further identify these subtle differences.

This work sets the stage for further genetic analysis of yeast prion propagation in E. coli.

To date, very few genomic approaches have focused on the analysis of the early molecular events in prion diseases and, to a lesser extent, studies dealing with the natural disease.

Our results show that this method is valuable for the biochemical typing of strains in voles and it is also a promising tool for molecular analysis of natural prion isolates.