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A biosynthetic route to produce d-glucaric acid from glucose has been constructed in Escherichia coli (Moon et al., 2009b), and analysis of the pathway revealed myo-inositol oxygenase (MIOX) to be the least active enzyme.
To assess the potential biological relevance of the pathway-specific perturbations, we concentrated on the analysis of the pathway showing the largest perturbations in the VD+ samples.
A detail analysis of the pathway differences is worthy of further investigation.
(XLSX 91 kb) Additional file 2: Enrichment analysis of the Pathway Commons Pathway of differentiated genes.
In the next section, we present the experimental results and analysis of the pathway intersections.
However these techniques analyze each gene separately rather than perform an analysis of the pathway at a systems level.
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We can further screen pathways and find the key pathways with the highest correlation with metabolites through comprehensive analysis of the pathways where the differential metabolites are located (including enrichment analysis and topological analysis).
This underlines that solar activity influences Earth processes and argues for a more complete analysis of the pathways through which this happens.
Miller and Solberg (2012) outlined the rationale for the separate analysis of the pathways to STEM.
An analysis of the pathways involving TLR2 and TLR4 reveal something about the way specific types of physical exercise are related to differences in the types of inflammatory responses they stimulate.
WI performed the analysis of the pathways for the degradation of aromatic compounds.
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