Analysis of the mutant fitness distributions with various mixing ratios is also useful to explore local fitness landscapes.
A genetic analysis of the mutant gene, mgl-1 tm1811), mgl-1 tm1811at suggestedn delayed thatonstarvationgenesis andelayedogenesis via MGL-1.
Analysis of the mutant spectra of virus populations selected with different concentrations of antibody in infections in liquid culture medium has documented a dominance of the high fitness counterpart in the selected population.
Analysis of the mutant phenotype in mice carrying a targeted disruption of the Wnt5a locus shows distinct abnormalities in distal lung morphogenesis as manifested by distinct truncation of the trachea and overexpansion of the distal respiratory airways.
Kinetic analysis of the mutant enzymes showed that the higher catalytic efficiency of the D77I and Y80F mutants toward α-naphthylbutyrate (C4) and α-naphthylcaprylate (C8), respectively, was due to a lower Km value.
Analysis of the mutant enzyme activities clearly demonstrated the importance of accessory clusters in retaining full enzyme activity at potentials around and higher than the equilibrium 2H+/H2 potential but not at the lowest potentials, where all enzymes have a similar turnover rate.
Whole-genome gene expression analysis of the mutant revealed 12 down-regulated genes within the mapped interval.
Crystallographic analysis of the mutant proteins showed that neither had any alteration in protein structure other than the expected changes at the mutation sites.
Herein, we describe the generation and analysis of the mutant strain deficient in the simReg1 gene, mobility shift DNA-binding assays of His-SimReg1 to putative promoter regions and propose a putative model for regulation of the biosynthesis and export of simocyclinones.
Analysis of the mutant channel expressed in HEK 293 cells reveals that the mutation produces both a huge decrease in current density and a significant shift to higher voltages of the current activation curve that was accompanied by the alteration of activation kinetics.
The background of this phenotype was further studied by co-transmission efficiency (TE) analysis of the mutant alleles.
