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The analysis of the inhibitory properties of this panel of compounds allowed a preliminary assessment of a structure activity relationship for the modification of the 4-amido and 5-amino groups of oseltamivir carboxylate.
Analysis of the inhibitory effect of mismatches in either the 5' or 3' end of the guide strand has demonstrated that the 5' end of the guide strand is likely responsible for matching and binding the target mRNA, while the 3' end is responsible for physically arranging target mRNA into a cleavage-favorable RISC region.
This method allows the analysis of the inhibitory effect of drugs within minutes instead of hours, identifying a direct effect on the putative targets before the cells react by modifying their FA composition to sustain normal membrane functions.
Detailed analysis of the inhibitory drug, chloranil, revealed that its inhibition of the clustering is due to the metalloproteinase-2-mediated ß-dystroglycan shedding and subsequent loss of laminin interaction with dystroglycan.
Analysis of the inhibitory actions of progesterone on follicle assembly using a microarray analysis of the ovarian transcriptome demonstrated that progesterone promoted a dramatic up-regulation of connective tissue growth factor (CTGF), as well as an increase in the TGFβ family member TGFβ-3 [33].
Quantitative analysis of the inhibitory effect by measuring the luciferase activity showed that in cells transfected with Luc+empty vector, the relative luciferase activity is 1936 light units, which are 37-fold higher than that in cells transfected with Luc+S.
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(C) Comparison and statistical analysis of the mean inhibitory effect of recombinant hTERT on BMP7-induced cell death.
Analysis of the growth inhibitory mechanism in DL cells revealed nuclear fragmentation, and condensation with the appearance of the sub-G0/G1 peak is indicative of apoptosis.
Analysis of the growth inhibitory mechanism in DL cells revealed nuclear fragmentation and condensation with appearance of the sub G0/G1 peak is indicative of apoptosis.
LC-MS and NMR spectral analysis of the most inhibitory fraction from P. homomalla subsequently identified prostaglandin A2 (PGas) as the dominant component.
Analysis of the fibril inhibitory activity for our somewhat small set of aryl analogs suggests that TTR inhibition scales with the size of the ortho-substituent, with 11 (CF3) and 13 (OMe) having the largest groups at this position.
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