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Detrended fluctuation analysis of stride length and stride time revealed that statistical persistence was unaffected by moderate muscle fatigue.
The systematic analysis of stride parameters across mice presented above provided a starting point for quantifying locomotor deficits of ataxic mice.
Further analysis of stride length data for the saline-treated MitoPark mice showed that stride length was highly variable (Fig. S4), which is most likely the cause of the unexpected result of L-DOPA-induced reduction of stride length.
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Data management and analysis of the STRIDE Study will be coordinated by the Yale DCC.
Watch: An analysis of the stride of the marathon runner Dathan Ritzenhein.
In their analysis of individual strides, researchers found that the ankle and toes seemed to be important predictors of acceleration.
Previous studies confirmed that stride-to-stride variability during walking is low [ 24] and hence the analysis of the typical stride is considered valid.
Analysis of gait width, stride length or overlap did not reveal any significant differences between both groups, but also failed to convincingly show differences over the course of disease between sham-treated R6/2 mice and wild-type controls (data not shown).
Table 2 reports the results of the adjusted analysis for the DTC of stride velocity.
* <.05; ** <.01; ***<.001 The adjusted analysis for the DTC of stride time and stride length are presented in Tables 3 and 4. R2 =.04 for preferred walking speed Step 1, Δ R2 =.20 for preferred walking speed Step 2 (p <.01); R2 =.22 for fast walking speed Step 1, Δ R2 =.28 for fast walking speed Step 2 (p <.001).
In this 20, an intention-to-treat analysis on the final measurement of stride length in the blinded-phase showed a statistically significant difference in favor of active treatment (p =.02).
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