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Quantitative analysis of renal uptake by SPECT and ex vivo measurements showed a very good correlation.
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Despite the lack of preclinical data on inhibition of renal uptake for peptides used for PSMA-RLT, AA co-administration was used in all patients included in this analysis.
Combining Gelofusine and lysine caused 70% reduction of renal uptake.
However, visual evaluation and an estimation of renal uptake made clear that the differences in renal uptake were far less than expected.
Therefore, increasing the Lys dose is not an option to improve the reduction of renal uptake.
This is a commonly used method nowadays, resulting in about 35% reduction of renal uptake of radioactivity [ 2, 13].
The mechanism of renal uptake of nephrotoxic heavy metals such as HgCl2 and NaAsO2 is not clear.
Calculation of renal uptake values was impaired by overprojection of activity in bowel and stomach that changed over time.
Small-animal SPECT is an accurate tool, allowing in vivo quantification of renal uptake and serial measurements in individual mice.
Heterogeneity of calcium compartmentation: electron probe analysis of renal tubules.
The renal function of mice was monitored by the determination of the renal uptake of 99mTc-DMSA using SPECT, as previously reported [22, 23].
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