However, these effects are not substantiated in a recent meta-analysis of multiple trials with data available for HER2 and TOP2A [ 8].
Furthermore, some recent review articles that performed meta-analysis of multiple trials reported that intensive glycemic control does not inevitably result in a reduction of cardiovascular events and mortality [ 31, 32].
Similarly, in a meta-analysis of multiple trials involving more than 31,000 patients with arthritis [ 30] there was no significant difference in MI frequency between patients taking celecoxib and those receiving placebo, any nonselective NSAID, or, specifically, naproxen, regardless of concomitant aspirin use.
For frequentist ITC, we used inverse variance weights to pool results of multiple trials in meta-analysis, and used the DerSimonian-Laird method for random-effects meta-analyses [ 22].
He also received compensation through payments to his employer for perform central MRI analysis of multiple sclerosis trials from Biogen Idec, GlaxoSmithKline, Merck, and Novartis.
In general, the preliminary information on which the trials were based, which was a small trial or a meta-analysis of multiple small trials, was not robust or predictive.
The survival argument is based solely on an as yet unpublished meta-analysis of multiple randomized trials of lumpectomy with or without radiation [ 24].
Meta-analysis of multiple randomized trials confirms that combining anthracycline-based chemotherapy with 5 years of tamoxifen, in women with HR+ve disease, reduces the risk of dying from breast cancer by ∼57% (Early Breast Cancer Trialists Collaborative Groupp, 2005).
In sorghum, a short day tropical species, meta-analysis of multiple QTL trials projected against a dense single-nucleotide polymorphism (SNP) map, suggests up to 17 loci affecting flowering time (Mace and Jordan 2011).
We conducted a CEA based on the clinical outcomes and measures of resource consumption obtained from a meta-analysis of multiple clinical trials, with costs obtained from the published literature, and reported from the broader perspective of the acute care hospital system.
